ENZYMIC ACTIVITIES AND SODIUM, POTASSIUM AND COPPER CONCENTRATIONS IN MOUSE BRAIN AND LIVER AFTER CUPRIZONE TREATMENT IN VIVO

Abstract— The oral administration of cuprizone to mice induces status spongiosus in the CNS and giant mitochondria in the liver. The activities of monoamine oxidase and cytochrome oxidase in brain and liver are inhibited and succinate dehydrogenase activity is increased. There is an increase in sodium and decrease in potassium concentrations; brain dry weight and copper content are decreased. Animals treated with copper-chelated cuprizone do not show any changes.