Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish

Authors:	Sa Kan Yoo Qing Deng Peter J Cavnar Yi I Wu Klaus M Hahn Anna Huttenlocher

Institution:	1. Program in Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, WI 53706, USA;2. Departments of Pediatrics and Medical Microbiology and Immunology, 4205 Microbial Sciences Building, 1550 Linden Drive, University of Wisconsin-Madison, Madison, WI 53706, USA;3. Department of Pharmacology and Lineberger Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA

Abstract:	Download : Download high-res image (220KB) Download : Download full-size image Highlights? Neutrophil motility in live zebrafish requires PI(3)K activity at the leading edge ? Localized photo-activation of Rac can to direct migration in vivo ? Rac activation rescues protrusion but not polarization in PI(3)K-inhibited cells ? Separable two-tier regulation of F-actin dynamics and protrusion by PI(3)K

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