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Kinetochores Generate Microtubules with Distal Plus Ends: Their Roles and Limited Lifetime in Mitosis
Authors:Etsushi Kitamura  Kozo Tanaka  Shinya Komoto  Yoko Kitamura  Claude Antony  Tomoyuki U. Tanaka
Affiliation:1. Wellcome Trust Centre for Gene Regulation & Expression, University of Dundee, Dundee DD1 5EH, UK;2. Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan;3. European Molecular Biology Laboratory, D-69117 Heidelberg, Germany
Abstract:
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  • Highlights? A short-lived population of kinetochore-derived microtubules (MTs) has distal plus ends ? These MTs are generated in early mitosis and regulated by Stu2 ? They interact with spindle pole-derived MTs before kinetochore attachment ? Once kinetochores attach to spindle-pole MTs, the short-lived MT population disappears
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