Ciglitazone is not itself thermogenic but increases the potential for thermogenesis in lean mice |
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Authors: | P. L. Thurlby S. Wilson J. R. S. Arch |
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Affiliation: | (1) Beecham Pharmaceuticals, Biosciences Research Centre, KT18 5XQ Epsom, Surrey, UK |
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Abstract: | Chronic dietary administration of the oral hypoglycaemic ciglitazone (3 g/day for 14–28 days) to lean, non-diabetic CD1 mice resulted in increased brown adipose tissue mitochondrial GDP binding and a marked increase in the thermic effect of the beta-adrenoceptor agonist BRL 26830A. However, ciglitazone was not itself thermogenic after an acute dose, nor did it raise resting metabolic rate during chronic dietary dosing. |
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Keywords: | ciglitazone thermogenesis brown adipose tissue GDP binding mice BRL 26830A beta agonist metabolic rate |
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