SARS患者痰液嗜麦芽窄食单胞菌的动态监测与意义

目的探讨嗜麦芽窄食单胞菌的动态检测对严重急性呼吸综合征（SARS）的临床意义.方法仪器和手工法动态监测3例重症和1例轻症患者痰液中嗜麦芽窄食单胞菌的定量变化和耐药性,同时观察K-B法药敏试验中L型的诱导情况及变异趋势.结果3例重症SARS患者共42次痰液和1次胸腔引流液培养中,35份分离出来嗜麦芽窄食单胞菌L型,形态以长丝体为主.结论动态监测重症SARS患者痰液中嗜麦芽窄食单胞菌有重要意义,多种抗生素可诱导其发生L型变异,应随时注意其变异趋势.

Dynamic monitoring of sputum Stenotrophomonas maltophilia in patients with severe acute respiratory syndrome

Objective To explore the clinical significance of dynamic observation of S. maltophilia in,patients with SARS. Methods S. maltophilia in sputum from 3 cases of critical and 1 of mild type patient with SAILS was examined continuously. L variation in antimicrobial susceptibility test performed by Kirby-Bauer method was also observed. Results 35 strains of S. maltophilia were isolated from 42 samples of sputum and one of hydrothorax,they were resistant to most antibiotics. Semi-fixed quantity of sputum correlated with the state of illness, and polymorphic S. maltophilia L-forms i.e. filamentous were found in bactefiostatic zone in K-B method. Conclusions Dynamic observation of S. maltophilia drug-resistance in patients with critical SARS was valuable, and it must pay attention that S. maltophilia may be induced to L-forms by many antibiotics.