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Primate genes for glycophorins carrying MN blood group antigens
Authors:Shinichi Kudo  Masaaki Onda  Ann Rearden  Minoru Fukuda
Abstract:Glycophorin A, B, and E genes were derived from a common ancestral gene and this gene family appeared during primate evolution, probably between orangutan and gorilla divergences. Based on the study of genomic structures of these human glycophorins and the genetic and immunological study of primate glycophorins, we hypothesize that chimpanzee and gorilla glycophorin B could possess a longer extracellular region and carry a stronger N blood group antigenicity compared with that of the human.
Keywords:membrane protein  gene evolution  primate phylogeny
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