Relationship between chimpanzee Rh-like genes and the R-C-E-F blood group system |
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| Authors: | I. Salvignol,A. Blancher,P. Calvas,W.W. Socha,Y. Colin,J.-P. Cartron,J. Ruffi |
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| Affiliation: | I. Salvignol,A. Blancher,P. Calvas,W.W. Socha,Y. Colin,J.-P. Cartron,J. Ruffié |
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| Abstract: | The antigenic closeness between the chimpanzee alloantigen Rc of the R-C-E-F system, and the human alloantigen Rho(D) suggests a phylogeconnection between their genes. To confirm at the molecular level the common origin of these genes, genomic DNA from 16 unrelated chimpanzees of various R-C-E-F phenotypes were digested by three restriction enzymes and analyzed by Southern blot using a human Rh cDNA probe and three exon-specific probes. Restrictions profiles displayed reach polymorphism. Correlations between some bands and certain R-C-E-F phenotypes demonstrate that the human Rh cDNA probe defines in chimpanzee genomic DNA some genes of the R-C-E-F system. |
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| Keywords: | molecular genetics Southern blot phylogeny Rh gene homology |
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