Preparative resolution of some 5,5-hydantoin derivatives via formation of diastereoisomeric salts |
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Authors: | G rard Coquerel,Marie-Noë lle Petit,Roger Bouaziz,Dominique Depernet |
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Affiliation: | Gérard Coquerel,Marie-Noëlle Petit,Roger Bouaziz,Dominique Depernet |
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Abstract: | Several preparative resolutions of 5,5-disubstituted hydantoins have been achieved via fractional crystallization of diastereoisomeric salts. The process can be extended by making use of the difference between the variation of solubilities of the hydantoins and their salts with α-methylbenzylamine as a function of the alkalinity of the medium. Optimization for each resolution procedure involves a refinement of the excess amount of base needed. © 1992 Wiley-Liss, Inc. |
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Keywords: | solvent basic medium competitive solubilities optimization optical resolution |
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