6'-Hydroxyoxosorbicillinol, a new lipoxygenase inhibitor and PGD2/LTB4 release suppressor from Penicillium sp

A new lipoxygenase inhibitor, 6'-hydroxyoxosorbicillinol (1, C(14) H(16)O(6)), was identified from a culture of Penicillium sp. A known compound, oxosorbicillinol (2, C(14)H(16)O(5)), was also isolated. Compound 1 showed an approximately 10 times greater inhibitory effect on soybean lipoxygenase (IC(50), 16 μM) than 2 (IC(50), 150 μM), and also showed prostaglandin D(2) (PGD(2)) and leucotriene B(4) (LTB(4)) release suppression activity (IC(50), 10 μM for PGD(2) and 100 μM for LTB(4)).