Protective capacity of virus-specific T cell receptor-transduced CD8 T cells in vivo |
| |
Authors: | Katja Mueller Anne von Mässenhausen Ulrike Aichele Lilian Stärck Matthias Leisegang Wolfgang Uckert Hanspeter Pircher |
| |
Institution: | Institute of Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany. |
| |
Abstract: | The transfer of T cell receptor (TCR) genes by viral vectors represents a promising technique to generate antigen-specific T cells for adoptive immunotherapy. TCR-transduced T cells specific for infectious pathogens have been described, but their protective function in vivo has not yet been examined. Here, we demonstrate that CD8 T cells transduced with the P14 TCR specific for the gp33 epitope of lymphocytic choriomeningitis virus exhibit protective activities in both viral and bacterial infection models in mice. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|