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Phage Application for the Protection from Acute Hepatopancreatic Necrosis Disease (AHPND) in |
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| Authors: | Jin Woo Jun Jee Eun Han Sib Sankar Giri Kathy F. J. Tang Xiaohui Zhou Luis Fernando Aranguren Hyoun Joong Kim Saekil Yun Cheng Chi Sang Guen Kim Se Chang Park |
| Affiliation: | 1.Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science,Seoul National University,Seoul,Republic of Korea;2.School of Animal and Comparative Biomedical Sciences,University of Arizona,Tucson,USA;3.Department of Pathobiology and Veterinary Science,University of Connecticut,Storrs,USA |
| Abstract: | Acute hepatopancreatic necrosis disease (AHPND) caused by Vibrio parahaemolyticus has been one of the most problematic diseases in marine shrimp aquaculture throughout Southeast Asia and Latin America. To evaluate the effectiveness of a bacteriophage (phage) treatment for AHPND, a series of bioassays were carried out in a marine shrimp (Penaeus vannamei) model using an AHPND-V. parahaemolyticus strain that is highly pathogenic to shrimp. We monitored the mortality and histopathological changes during phage treatment. Shrimps treated with phage prophylaxis and phage therapy displayed significant protection from AHPND and survived a lethal bacterial challenge. |
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