Neural mechanisms and computations underlying stress effects on learning and memory |
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Authors: | Luksys Gediminas Sandi Carmen |
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Institution: | 1 Division of Cognitive Neuroscience, University of Basel, Birmannsgasse 8, CH-4055 Basel, Switzerland 2 Division of Molecular Neuroscience, University of Basel, Missionsstrasse 60/62A, CH-4055 Basel, Switzerland 3 Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne (EPFL), Station 19, CH-1015 Lausanne, Switzerland |
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Abstract: | Stress has complex effects on memory function that can vary depending on the type of information that is learned and in relation to inter-individual characteristics. Recent work has also shown that stress can switch performance between memory systems, biasing it toward habit in detriment of spatial or goal-directed strategies. In addition, novel synaptic mechanisms have been implicated in the effects of stress in plasticity and memory. Computational modeling is emerging as a useful approach to integrate and to ascertain neural and cognitive computations underlying different effects of stress in memory. Having provided novel explanations for the inverted-U-shaped relationship between stress and cognitive performance, model-based analysis studies can improve our understanding of diverse effects of stress in cognition and psychopathology. |
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