Neurobiology of obsessive-compulsive disorder: insights into neural circuitry dysfunction through mouse genetics |
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Authors: | Ting Jonathan T Feng Guoping |
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Institution: | 1 Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA 2 McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 3 Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA 02142, USA |
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Abstract: | The precise causal factors for obsessive-compulsive disorder (OCD) are not known, although, decades of research have honed in on the cortico-striatal-thalamo-cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimately linked compulsive-repetitive behaviors. Recent progress in human and mouse genetics have led to the identification of novel candidate susceptibility genes, which in turn have facilitated a more focused approach to unraveling the nature of circuitry dysfunction in OCD. The ability to perform invasive techniques in genetic animal models of OCD will be crucial for rapid advances in this field, and as such we review the most recent developments and highlight the importance of searching out common circuitry defects underlying compulsive-repetitive behaviors. |
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