Mapping of two genetic loci,Ten-1 and Ten-2, associated with thymus enlargement in BUF/Mna rats |
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| Authors: | Y Murakumo M Takahashi N Sharma A Arakawa M Saito H Amo M Matsuyama |
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| Institution: | (1) Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466, Japan, JP;(2) Department of Obstetrics and Gynecology, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan, JP;(3) Aichi Women's College, 57 Takenoyama, Iwasaki, Nisshin-shi, Aichi-ken 470-01, Japan, JP;(4) Department of Pathology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi, Aichi-ken 470-11, Japan, JP |
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| Abstract: | The thymoma-prone BUF/Mna rat is a useful model for human thymoma. Thymoma develops spontaneously in these rats at an incidence
of nearly 100%. At pre-thymoma age, BUF/Mna rats have extremely large thymuses when compared with those of rats of the other
strains, suggesting the presence of genes that regulate the thymus enlargement. We performed linkage study to identify the
genetic loci associated with thymus enlargement in {(WKY/NCrj × BUF/Mna) F1× BUF/Mna} backcross rats. Linkage study showed the significant associations between thymus size and markers on Chromosomes
(Chrs) 1 and 13, suggesting the presence of two genes, Ten-1 and Ten-2, which regulate the thymus enlargement. Ten-1 was located between myosin light chain, muscle 2 (MYL2) and D1Mgh11 loci on Chr 1, and Ten-2 was located between synaptotagmin II (SYT2) and D13N2 loci on Chr 13.
Received: 6 November 1995 / Accepted: 29 March 1996 |
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