Biochemical genetics of methylglyoxal dehydrogenases in the laboratory rat (Rattus norvegicus) |
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| Authors: | K. Bender R. T. Seibert T. F. Wienker V. Kren M. Pravenec S. Bissbort |
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| Affiliation: | (1) Institut für Humangenetik und Anthropologie der Universität Freiburg, Breisacher Str. 33, D-79106 Freiburg, Germany;(2) Biologicky Ustav, University Karlovy, Albertov 4, 12800 Praha, !["Ccaron"]("/content/m52q0523705w4144/xlarge268.gif") eska Republika;(3) Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 14220 Praha 4, KR, eska Republika |
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| Abstract: | A genetic locus controlling the electrophoretic mobility of a methylglyoxal dehydrogenase (EC 1.2.1.23) in the rat is described. The locus, designatedMgd1, is expressed in liver and kidney. Inbred rat strains have fixed either alleleMgd1a or alleleMgd1b. Codominant expression is observed in heterozygotes, providing evidence for a tetrameric enzyme structure. Backcross progenies showed the expected 1:1 segregation ratio, and there is evidence thatMgd1 is linked toPep3 andFh1 on chromosome 13. There is also evidence for two additional methylglyoxal dehydrogenases:Mgd2, present in liver and kidney, andMgd3, present only in heart.Supported by the Deutsche Forschungsgemeinschaft (Grant Be 352/18-1). |
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| Keywords: | methylglyoxal methylglyoxal dehydrogenase loci 1, 2, 3 Mgd1 polymorphism heart-specificMgd3 expression glyoxalase I rat chromosome 13 |
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