Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers |
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| Authors: | Lee Jae Yeol Park Seong Jun Park Sung Jun Lee Min Joo Rhim Hyewhon Seo Seon Hee Kim Ki-Sun |
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| Institution: | Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, 1 Hoegi-Dong, Seoul 130-701, Republic of Korea. ljy@khu.ac.kr |
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| Abstract: | This paper describes the preliminary biological results that novel T-type calcium channel blockers inhibit the growth of human cancer cells by blocking calcium influx into the cell, based on unknown mechanism on the cell cycle responsible for cellular proliferation. Among the selected compounds from compound library, compound 9c (KYS05041) was identified to be nearly equipotent with Cisplatin against some human cancers in the micromolar range. |
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