Inhibition of Src kinase activity by 4-anilino-5,10-dihydro-pyrimido[4,5-b]quinolines |
| |
| Authors: | Boschelli Diane H Powell Dennis Golas Jennifer M Boschelli Frank |
| |
| Institution: | Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, NY 10965, USA. bosched@wyeth.com |
| |
| Abstract: | 4-(2,4-Dichloro-5-methoxy)anilino-5,10-dihydropyrimido4,5-b]quinolines are potent inhibitors of Src kinase and Src cellular activity while having no effect on Fyn cellular activity. The corresponding 4-(2,4-dichloro-5-methoxy)anilino-pyrimido4,5-b]quinolines are much less effective Src inhibitors. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
