Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells |
| |
Authors: | Waithman Jason Allan Rhys S Kosaka Hiroshi Azukizawa Hiroaki Shortman Ken Lutz Manfred B Heath William R Carbone Francis R Belz Gabrielle T |
| |
Institution: | Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia. |
| |
Abstract: | Skin-draining lymph nodes contain a number of dendritic cell (DC) subsets of different origins. Some of these are migratory, such as the skin-derived epidermal Langerhans cells and a separate dermal DC subset, whereas others are lymphoid resident in nature, such as the CD8+ DCs found throughout the lymphoid tissues. In this study, we examine the DC subset presentation of skin-derived self-Ag by migratory and lymphoid-resident DCs, both in the steady state and under conditions of local skin infection. We show that presentation of self-Ag is confined to skin-derived migrating DCs in both settings. Steady state presentation resulted in deletional T cell tolerance despite these DCs expressing a relatively mature phenotype as measured by traditional markers such as the level of MHC class II and CD86 expression. Thus, self-Ag can be carried to the draining lymph nodes by skin-derived DCs and there presented by these same cells for tolerization of the circulating T cell pool. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|