Identification of a novel glycosyltransferase involved in LOS biosynthesis of Moraxella catarrhalis |
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Authors: | Wilson Jennifer C Collins Patrick M Klipic Zoran Grice I Darren Peak Ian R |
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Affiliation: | Institute for Glycomics, Griffith University, Gold Coast, 4215 QLD, Australia. |
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Abstract: | Moraxella catarrhalis is an important human mucosal pathogen that contributes to otitis media in infants and exacerbates conditions such as chronic obstructive pulmonary disease in the elderly. This study describes the identification of a novel gene, lgt5 that encodes a glycosyltransferase involved in the LOS biosynthesis of M. catarrhalis. Analysis of NMR data of LOS-derived oligosaccharide from a Serotype A lgt5 mutant strain of M. catarrhalis indicate that lgt5 encodes an alpha-(1-->4)-galactosyltransferase. |
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Keywords: | Glycosyltransferases Lipooligosaccharide Insertional inactivation Moraxella catarrhalis NMR spectroscopy |
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