Alteration of signal-transducing molecules in tumor-infiltrating lymphocytes and peripheral blood T lymphocytes from human colorectal carcinoma patients |
| |
Authors: | Choi S H Chung Eun Joo Whang Dae Yong Lee Seung Sook Jang Yong-Suk Kim C W |
| |
Institution: | (1) Department of Pathology, Cancer Research Center, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Korea Tel.: +82 2 740 8267; Fax: +82 2 765 5600, KR;(2) Department of Surgery, Korea Cancer Center Hospital, Korea, KR;(3) Department of Pathology, Korea Cancer Center Hospital, Korea, KR;(4) Faculty of Biological Sciences and The Institute for Molecular Biology and Genetics, Chonbuk National University, Chonju 561-756, Korea, KR |
| |
Abstract: | Tumor development or growth is accompanied by impaired immune responses, such as a poor proliferative response or down-regulated
cytolytic T lymphocyte activity. Although recent reports have suggested that modification of the signal-transducing molecule
is responsible for impaired immune responses in tumor-bearing hosts, the causes of defective immune function are not yet completely
understood. Furthermore, the clinical significance of the findings is not yet clear. In this study, we investigated the alteration
of several signal-transducing molecules in peripheral blood T lymphocytes (T-PBL) as well as in tumor-infiltrating lymphocytes
(TIL) from human colorectal carcinoma patients and their relationship with the impaired host immune responses. A greater reduction
in CD3ζ chain level was observed in TIL than in T-PBL from tumor-bearing hosts. CD3ζ chain reduction in T-PBL correlated with
the clinicopathological stage of a tumor, especially with the status of lymph node metastasis. The levels of p56
lck
and p59
fyn
protein tyrosine kinase in T-PBL were also compared between tumor-bearing hosts and normal healthy volunteers. In T-PBL from
tumor-bearing hosts, expression of protein tyrosine kinase p59
fyn
was significantly lower than that of p56
lck
. However, the level of CD3ζ chain expression did not correlate with T lymphocyte functions such as T lymphocyte proliferative
response or allogeneic target cell lysis.
Received: 25 September 1996 / Accepted: 25 August 1997 |
| |
Keywords: | TCR-CD3 TIL Colorectal cancer Protein tyrosine kinase (PTK) Immune suppression |
本文献已被 SpringerLink 等数据库收录! |
|