The diurnal variation of immunoreactive adrenocorticotropin in rhesus monkey plasma and cerebrospinal fluid |
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Authors: | N H Kalin S E Shelton C M Barksdale M Carnes |
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Affiliation: | 1. Psychiatry Section and Geriatrics Section William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA;1. Department of Psychiatry and Medicine University of Wisconsin Medical School, Madison, Wisconsin, USA |
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Abstract: | ACTH immunoreactivity (ACTH-IR) in the plasma and cerebrospinal fluid (CSF) collected simultaneously from rhesus monkeys was found to undergo significant diurnal variations. In plasma, the mean peak ACTH-IR was 15.4 +/- 1.95 pg/ml at 0500 h, and the mean minimum concentration was 9.05 +/- 1.80 pg/ml at 1800 h. In CSF, the mean peak ACTH-IR concentration occurred at 1900 h and was 4.64 +/- 0.41 pg/ml. The mean minimum CSF ACTH-IR concentration was 2.93 +/- 0.26 pg/ml, occurring at 0500 h. This is the first report of a diurnal variation in CSF ACTH-IR concentration and is consistent with other work suggesting that plasma ACTH and CSF ACTH originate from different sources. |
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Keywords: | Address correspondence and reprint requests to: Ned H. Kalin M.D. Psychiatry Section William S. Middleton Memorial Veterans Hospital 2500 Overlook Terrace Madison WI 53705 USA. |
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