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Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines |
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| Authors: | Perry Benjamin Alexander Rikki Bennett Gavin Buckley George Ceska Tom Crabbe Tom Dale Verity Gowers Lewis Horsley Helen James Lynwen Jenkins Kerry Crépy Karen Kulisa Claire Lightfoot Helen Lock Chris Mack Stephen Morgan Trevor Nicolas Anne-Lise Pitt Will Sabin Verity Wright Sara |
| Institution: | UCB, Medicinal Chemistry, Granta Park, Great Abington, Cambridge CB21 6GS, UK. bengperry@yahoo.co.uk |
| Abstract: | The SAR and pharmacokinetic profiles of a series of multi-isoform PI3K inhibitors based on a 3,4-dihydro-2H-benzo1,4]oxazine scaffold are disclosed. |
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