Assessment of the antidiabetic activity of epicatechin in streptozotocin-diabetic and spontaneously diabetic BB/E rats |
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| Authors: | A J bone C S T Hii D Brown W Smith S L Howell |
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| Institution: | (1) Metabolic Unit, Western General Hospital, Edinburgh, U.K.;(2) Department of Physiology, Queen Elizabeth College, W8 7AH London, U.K. |
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| Abstract: | (–)-Epicatechin has previously been suggested to rapidly reverse alloxan diabetes in rats. We have assessed the therapeutic value of the compound in two further animal models of insulin-dependent diabetes mellitus, namely streptozotocin - diabetic rats and the spontaneously diabetic BB/E rat . There was no indication of a reversal of established diabetes in either the streptozotocin-diabetic or the spontaneously diabetic BB/E rats. Moreover, epicatechin also failed to halt the progression of the disease in prediabetic BB/E rats. Earlier claims of the potential use of epicatechin as an antidiabetic agent must therefore be treated with some caution. |
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