Repeat element-driven activation of proto-oncogenes in human malignancies |
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| Authors: | Bj?rn Lamprecht Constanze Bonifer Stephan Mathas |
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| Affiliation: | 1.Max-Delbrück Center for Molecular Medicine; Charité-Universitätsmedizin Berlin; Campus Virchow-Klinikum; Berlin, Germany;2.Hematology, Oncology and Tumorimmunology; Charité-Universitätsmedizin Berlin; Campus Virchow-Klinikum; Berlin, Germany;3.Section of Experimental Haematology; Leeds Institute of Molecular Medicine; University of Leeds; St. James''s University Hospital; Leeds, UK |
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| Abstract: | Recent data demonstrated that the raberrant activity of endogenous repetitive elements of the DNA in humans can drive the expression of proto-oncogenes. This article summarizes these results and gives an outlook on the impact of these findings on the pathogenesis and therapy of human cancer.Key words: LTR, Hodgkin lymphoma, CSF-1 receptor, epigenetic reprogramming, DNA methylation |
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