Antioxidative activities of galloyl glucopyranosides from the stem-bark of Juglans mandshurica |
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Authors: | Ngoc Tran Minh Hung Tran Manh Thuong Phuong Thien Kim Jin-Cheon Choi Jae Sue Bae KiHwan Hattori Masao Choi Chung-Sig Lee Joon Seok Min Byung-Sun |
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Institution: | College of Pharmacy, Chungnam National University, Daejeon, Korea. |
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Abstract: | Two phenolics, 1,2,6-trigalloylglucose (1) and 1,2,3,6-tetragalloylglucose (2), isolated from the stem-bark of Juglans mandshurica were evaluated for their antioxidative activities. The results showed that compounds 1 and 2 exhibited strong scavenging activities against 1,1'-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-(3-ethylbenzenthiazoline-6-sulphonic) acid (ABTS(*+)), and superoxide radicals (O(2)(*-)), and also had a significant inhibitory effect on lipid peroxidation and low-density lipoprotein (LDL) oxidation. The strong superoxide radical scavenging of 1 and 2 resulted from the potential competitive inhibition with xanthine at the active site of xanthine oxidase (OX). In addition, compounds 1 and 2 displayed significant lipoxygenase inhibitory activity, the mode of inhibition also being identified as competitive. In comparison, the antioxidative activities of compounds 1 and 2, together with gallic acid, indicated that the number of galloyl moieties could play an important role in the antioxidative activity. |
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