Determination of branched beta-cyclodextrin-prostaglandin complexes using electrospray ionization mass spectrometry |
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Authors: | Yamane Naoe Tozuka Zenzaburo Okada Yasuyo Honda Chie Nishi Yuki Tanimoto Toshiko |
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Institution: | JCL Bioassay Corporation, Nishiwaki, Japan. n.yamane@jclbio.com |
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Abstract: | Mass spectral measurements by electrospray ionization mass spectrometry (ESI-MS) detected the ions of beta-cyclodextrin (betaCD) or branched betaCDs (glucosyl-, galactosyl-, mannosyl- and maltosyl-betaCD)-prostaglandins (PGs: PGA(2), PGD(2), PGE(1), PGE(2), PGF(2alpha) and PGJ(2)) complexes, i.e., betaCD-PG complexes, with a host:guest ratio of 1:1 in the negative ion mode. This is the first study to report the ions of branched betaCD-PG complexes using ESI-MS. The inclusion complexes were determined by a flow injection analysis using acetonitrile/water. We could confirm by this method the presence of a betaCD-PGE(2) complex with a host:guest ratio of 1:1 in a solution-dissolved pharmaceutical formulation consisting of betaCD-PGE(2) (Prostarmon E tablet). |
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