Brain cholecystokinin depletion in rats with acute liver failure |
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| Authors: | C Bonato A Malesci R Rosati F Vignati M Montorsi M Bersani R Abbiati F Salerno |
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| Institution: | Instituti di Medicina Interna e di Clinica Chirurgica I, Ospedale Policlinico-Università di Milano, Italy. |
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| Abstract: | A decrease of both hypothalamic and cortical CCK occurred in the brain of rats killed 8 hours after hepatic artery ligation following portocaval anastomosis. Brain CCK depletion was not reproduced by exogenously provoked hyperammonemia nor by insulin-induced hypoglycemia, thus suggesting a central mechanism for the derangement of the CCKergic system in the course of acute liver failure. |
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