Changes in circadian rhythms of thermoregulation and motor activity in rats as a function of aging: Effects of d-amphetamine and α-MSH |
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Authors: | Shlomo Yehuda Ralph L. Carasso |
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Abstract: | Thermoregulatory and motor activity circadian cycles are age-dependent. While the level of thermoregulation and motor activity remained almost at the same level during the first 1–15 months during the light portion of the 24-hr cycle, a significant decrease in the level of both rhythms was observed during the dark period. Therefore, older rats exhibited reversed cycles compared with younger rats. Treatments with d-amphetamine resulted in the enhancement of reversal of the cycles. Rats treated with α-MSH failed to exhibit a reversal of the cycles. While the effects of d-amphetamine are mediated by the brain DA mesolimbic pathway, it seems that α-MSH acts on the dopaminergic system at different sites of action. |
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Keywords: | Aging Circadian rhythms Thermoregulation Motor activity d-Amphetamine α -MSH |
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