The use of high-pressure liquid chromatography in the preparation of tritium-labeled chloramphenicol and its analogs. |
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| Authors: | J L Martin A M Taburet L R Pohl |
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| Affiliation: | Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205 USA |
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| Abstract: | The 1-hydroxy epimers of chloramphenicol and thiamphenicol formed from the reduction of the respective 1-oxo derivatives with [3H]NaBH4 have been separated preparatively by high-pressure liquid chromatography on a μBondapak C18 column. This separation procedure permits the facile and rapid preparation of the 1-3H-labeled derivatives of chloramphenicol and its analogs. |
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| Keywords: | To whom reprint requests should be sent. |
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