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Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories |
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| Authors: | Plath Niels Ohana Ora Dammermann Björn Errington Mick L Schmitz Dietmar Gross Christina Mao Xiaosong Engelsberg Arne Mahlke Claudia Welzl Hans Kobalz Ursula Stawrakakis Anastasia Fernandez Esperanza Waltereit Robert Bick-Sander Anika Therstappen Eric Cooke Sam F Blanquet Veronique Wurst Wolfgang Salmen Benedikt Bösl Michael R Lipp Hans-Peter Grant Seth G N Bliss Tim V P Wolfer David P Kuhl Dietmar |
| Institution: | Molecular Neurobiology, Department of Biology-Chemistry-Pharmacy, Freie Universit?t Berlin, 14195 Berlin, Germany. |
| Abstract: | Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage. |
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