The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice |
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Authors: | Marakalala Mohlopheni J Guler Reto Matika Lungile Murray Graeme Jacobs Muazzam Brombacher Frank Rothfuchs Antonio Gigliotti Sher Alan Brown Gordon D |
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Affiliation: | Division of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa. |
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Abstract: | There is interest in identifying the pattern recognition receptors involved in initiating protective or non-protective host responses to Mycobacterium tuberculosis (Mtb). Here we explored the role of the Syk/CARD9-coupled receptor, Dectin-1, using an aerosol model of Mtb infection in wild-type and Dectin-1 deficient mice. We observed a reduction in pulmonary bacilli burdens in the Dectin-1 deficient animals, but this did not correlate with significant changes in pulmonary pathology, cytokine levels or ability of these animals to survive the infection. Thus Dectin-1 makes a minor contribution to susceptibility to Mtb infections in mice. |
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