CHEMICAL SYNTHESIS OF THE NOVEL CA2+ MESSENGER NAADP

The first total chemical synthesis of nicotinamide adenine dinucleotide phosphate (β-NADP, 2) as a single isomer was achieved. This was subsequently converted into the important second messenger nicotinic acid adenine dinucleotide phosphate (β-NAADP) 1 and the identity of this material confirmed by biological evaluation. This flexible synthetic route offers new opportunities for the generation of NAADP 1 analogues that cannot be generated directly from NADP 2 or mainly enzymatic methods.