Synthesis of 5-Azacytidine Nucleosides with Rigid Sugar Moiety as Potential Antitumor Agents

Abstract

The bicyclic 3′-O,5′-C-methylene-linked and 2′-O,5′-C-methylene-linked 5-azacytidine derivatives were readily synthesized from 1,2;5,6-di-O-isopropylidene-d-glucose and evaluated against several cancer cell lines.