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MODEL SYNTHESIS OF NUCLEOSIDE BORANOPHOSPHORAMIDATE WITH AMINO ACID FOR PRODRUG PURPOSE |
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| Abstract: | A model synthesis of a nucleoside boranophosphoramidate prodrug with (L)-tryptophan methyl ester was accomplished in a one-pot reaction via an H-phosphonate approach. This new type of compound is expected to possess the potent antiviral and anticancer advantages conferred by boranophosphates and normal nucleoside amino acid phosphoramidate. |
| Keywords: | Nucleoside Boranophosphoramidate Amino Acid Prodrug H-Phosphonate |