SYNTHETIC STUDY OF 3′-α-FLUORO-2′,3′-DIDEOXYGUANOSINE |
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Abstract: | A synthetic method was established for 3′-α-fluoro-2′,3′-dideoxyguanosine 1 from guanosine 2 in 27% overall yield and 6 steps. A byproduct 6a of fluorination was identified by NMR studies, its presence strongly supporting our supposition that the fluorination itself proceeded via a bromonium cation. |
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Keywords: | 3′-α-fluoro-2′ 3′-dideoxyguanosine |
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