Novel Nucleotide Analogues as Potential Substrates for TMPK,a Key Enzyme in the Metabolism of AZT |
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Abstract: | Abstract Novel cyclic and acyclic analogues of dTMP and AZTMP were synthesized from the corresponding cycloSal-phosphotriesters. This method yielded the nucleotides in good yields with a simple work-up. Investigation of the substrate properties of the modified nucleotides towards TmpK showed, that they are very poor substrates for this key enzyme in the bioactivation of AZT. |
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