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Synthesis and Biological Evaluation of Halo-neplanocin A as Novel Mechanism-Based Inhibitors of S-Adenosylhomocysteine Hydrolase |
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| Abstract: | Abstract Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase. |
| Keywords: | Halo-neplanocin A S-Adenosylhomocysteine hydrolase Mechanism-based inhibitor |