可德兰多糖载药微粒的构建、表征及其缓释作用

利用具有三螺旋结构的可德兰多糖作为载体,制备二十二碳六烯酸(DHA)的载药微粒。利用粒径、表面电位测定、红外光谱法、粉末X-射线衍射法等方式表征其载药微粒,并分析了载药微粒的体外缓释作用。结果表明,载药微粒平均载药量为6.4%,包封率为56.6%,平均有效粒径为291 nm。红外光谱法、粉末X-射线衍射等分析均表明形成了以可德兰多糖为主体的载药微粒,结晶度的降低能够增加载药微粒的溶解度。另外,体外缓释实验也证明了载药微粒具有一定的缓释性能。可德兰多糖作为载体制备的载药微粒具有一定的缓释性,在食品或医药行业中有广泛的利用前景。并为多糖作为载体构建具有一定缓释性的载药微粒的研究提供了理论依据。

Construction,Characterization and Sustained Release of Drug-Loaded Particles of Curdlan

The drug-loaded microparticles of docosahexaenoic acid(DHA)were prepared using a curdlan having a triple helix structure as a carrier.The prepared drug-loaded microparticles were characterized by particle size,surface potential measurement,infrared spectroscopy,powder X-ray diffraction,etc.,and the in vitro sustained release of drug-loaded microparticles was investigated.The results showed that the average drug loading of the drug-loaded particles was 6.4%,the encapsulation efficiency was 56.6%,and the average effective particle size was 291 nm.Infrared spectroscopy,powder X-ray diffraction and the like all showed that drug-loaded microparticles mainly composed of curdlan were formed.In addition,the in vitro sustained release experiment also proved that the drug-loaded particles have a certain sustained release property.The drug-loaded microparticles prepared from the curdlan as a carrier have a certain sustained release property,which is beneficial to the wide use of curdlan polysaccharide in the food or pharmaceutical industry.