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Expression of miRNAs in ovine fetal gonads: potential role in gonadal differentiation |
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| Authors: | Katie J Torley Juliano C da Silveira Peter Smith Russell V Anthony DN Rao Veeramachaneni Quinton A Winger Gerrit J Bouma |
| Affiliation: | (1) Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, 80523 Fort Collins, CO, USA;(2) AgResearch Limited, Invermay, Research Centre Mosgiel, Wellington, New Zealand |
| Abstract: | BackgroundGonadal differentiation in the mammalian fetus involves a complex dose-dependent genetic network. Initiation and progression of fetal ovarian and testicular pathways are accompanied by dynamic expression patterns of thousands of genes. We postulate these expression patterns are regulated by small non-coding RNAs called microRNAs (miRNAs). The aim of this study was to identify the expression of miRNAs in mammalian fetal gonads using sheep as a model. |
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