Module-based multiscale simulation of angiogenesis in skeletal muscle |
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| Authors: | Gang Liu Amina A Qutub Prakash Vempati Feilim Mac Gabhann Aleksander S Popel |
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| Affiliation: | (1) Systems Biology Laboratory, Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA;(2) Department of Bioengineering, Rice University, Houston, TX 77521, USA;(3) Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA |
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| Abstract: | Background Mathematical modeling of angiogenesis has been gaining momentum as a means to shed new light on the biological complexity underlying blood vessel growth. A variety of computational models have been developed, each focusing on different aspects of the angiogenesis process and occurring at different biological scales, ranging from the molecular to the tissue levels. Integration of models at different scales is a challenging and currently unsolved problem. |
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