Cre-LoxP-regulated expression of monoclonal antibodies driven by an ovalbumin promoter in primary oviduct cells |
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| Authors: | Isao Oishi Sungtae Kim Kyoko Yoshii Concepcion Rodriguez Esteban Juan Carlos Izpisua Belmonte |
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| Institution: | (1) Health Research Institute, National Institute of Advanced Industrial Science and Technology, 1-8-31, Midorioka, 563-8577 Ikeda, Osaka, Japan;(2) Department of Chemistry, Korea University, 136-701 Seoul, Korea;(3) Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Rd., 92037 La Jolla, CA, USA;(4) Center of Regenerative Medicine in Barcelona, Dr. Aiguader, 88, 08003 Barcelona, Spain |
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| Abstract: | Background A promoter capable of driving high-level transgene expression in oviduct cells is important for developing transgenic chickens
capable of producing therapeutic proteins, including monoclonal antibodies (mAbs), in the whites of laid eggs. Ovalbumin promoters
can be used as oviduct-specific regulatory sequences in transgenic chickens, but their promoter activities are not high, according
to previous reports. |
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