Extracellular crosstalk: when GDNF meets N-CAM |
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| Authors: | Zhou Feng Quan Zhong Jian Snider William D |
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| Affiliation: | UNC Neuroscience Center, Neuroscience Research Building, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA |
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| Abstract: | N-CAM has now been identified as a receptor for glial cell line-derived neurotrophic factor (GDNF). This finding solves a long-standing question regarding RET-independent GDNF signaling, and reveals a novel pathway distinct from both GDNF-RET and N-CAM-N-CAM signaling. Functional assays of Schwann cell migration and axon growth of CNS neurons suggest physiological significance for this GDNF-N-CAM pathway. |
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