Anti-Helicobacter pylori agents endowed with H2-antagonist properties |
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| Authors: | Sorba G Bertinaria M Di Stilo A Gasco A Scaltrito M M Brenciaglia M I Dubini F |
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| Affiliation: | Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università degli Studi del Piemonte Orientale, Novara, Italy. |
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| Abstract: | New anti-Helicobacter pylori (H. pylori) agents endowed with H2-antagonists properties were obtained by combining the lamtidine derived pharmacophoric group with the antibiotic calvatic acid. All the compounds were tested for their irreversible H2-antagonist properties and for their ability to inhibit 20 H. pylori strains, two of them metronidazole resistant. The most active derivative (compound 4) displayed antimicrobial activity similar to metronidazole. |
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