A latex lectin from <Emphasis Type="Italic">Euphorbia trigona</Emphasis> is a potent inhibitor of fungal growth |
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Authors: | N?van?Deenen D?Prüfer Email author" target="_blank">C?Schulze GronoverEmail author |
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Institution: | 1.Institute for Biochemistry and Biotechnology of Plants,Westphalian Wilhelms-University Muenster,Münster,Germany;2.Fraunhofer Institute for Molecular Biology and Applied Ecology,Aachen,Germany |
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Abstract: | In this study we identified and characterized a major latex lectin — designated as EtLLH — with antimicrobial activity from
the succulent African milk tree Euphorbia trigona. The lectin is highly concentrated in the latex of E. trigona and appears to be composed of at least two subunits with a molecular mass of 32 kDa. EtLLH shares significant similarities
to known plant lectins — ricin from Ricinus communis and agglutinin from Viscum album coloratum — which specifically bind D-galactose and N-acetyl-D-glucosamine, the major building blocks of many fungal cell walls. Antimicrobial
activity assays revealed an impact of EtLLH on three phytopathogenic filamentous ascomycetes. The germination of the conidiospores
and the hyphal growth of Aspergillus niger and Fusarium graminearum were severely inhibited by EtLLH already at concentrations below 0.1 mg cm−3, while the effect on germination of the melanized conidiospores of Botrytis cinerea was less significant. |
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