Systematic analysis of insertions and deletions specific to nematode proteins and their proposed functional and evolutionary relevance |
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| Authors: | Zhengyuan Wang John Martin Sahar Abubucker Yong Yin Robin B Gasser and Makedonka Mitreva |
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| Institution: | (1) The Genome Center, Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA;(2) Department of Veterinary Science, The University of Melbourne, Werribee, VIC, 3030, Australia |
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| Abstract: | Background Amino acid insertions and deletions in proteins are considered relatively rare events, and their associations with the evolution
and adaptation of organisms are not yet understood. In this study, we undertook a systematic analysis of over 214,000 polypeptides
from 32 nematode species and identified insertions and deletions unique to nematode proteins in more than 1000 families and
provided indirect evidence that these alterations are linked to the evolution and adaptation of nematodes. |
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