Polymorphism in the flanking regions of the PbGP43 gene from the human pathogen Paracoccidioides brasiliensis: search for protein binding sequences and poly(A) cleavage sites |
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| Authors: | Antonio A Rocha Flávia V Morais Rosana Puccia |
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| Affiliation: | (1) Department of Microbiology, Immunology and Parasitology, Federal University of S?o Paulo (UNIFESP), 04023-062 S?o Paulo, SP, Brazil;(2) Laboratory of Molecular Genetics and Genomics, University of Vale do Para?ba (UNIVAP), SP, Brazil |
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| Abstract: | Background Paracoccidioides brasiliensis is a thermo-dimorphic fungus that causes paracoccidiodomycosis (PCM). Glycoprotein gp43 is the fungal main diagnostic antigen, which can also protect against murine PCM and interact with extracellular matrix proteins. It is structurally related to glucanases, however not active, and whose expression varies considerably. We have presently studied polymorphisms in the PbGP43 flanking regions to help understand such variations. |
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