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O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists |
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| Authors: | Adams Alan D Hu Zao von Langen Derek Dadiz Adonis Elbrecht Alex MacNaul Karen L Berger Joel P Zhou Gaochao Doebber Thomas W Meurer Roger Forrest Michael J Moller David E Jones A Brian |
| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co. Inc., PO Box 2000 Rahway, NJ 07065, USA. alan_adams@merck.com |
| Abstract: | A new class of O-arylmandelic acid PPAR agonists show excellent anti-hyperglycemic efficacy in a db/db mouse model of DM2. These PPARalpha-weighted agonists do not show the typical PPARgamma associated side effects of BAT proliferation and cardiac hypertrophy in a rat tolerability assay. |
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