Dietary beta- and gamma-cyclodextrins stimulation of hepatic metallothionein gene expression in rats |
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Authors: | Kaewprasert S Okada M Aoyama Y |
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Institution: | Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan. |
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Abstract: | This study investigated whether hepatic metallothionein gene expression is affected by dietary cyclodextrins. Young male Wistar rats were fed a basal diet or cyclodextrin-supplemented (50 g of cyclodextrin per kg diet) diets for 7 d. Copper content in the liver did not show any significant changes among rats fed the basal, beta- and gamma-cyclodextrin diets. There were no differences in liver or serum zinc among groups. Copper content in serum was markedly decreased in rats fed the gamma-cyclodextrin-supplemented diet. Liver metallothionein mRNA levels were significantly elevated in both beta- and gamma-cyclodextrins-fed rats, but not in alpha-cyclodextrin-fed rats. Thus, the increase in hepatic metallothionein mRNA levels might be due to this mechanism except for the contents of copper and zinc in the liver. |
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