Synthesis and ITC characterization of novel nanoparticles constituted by poly(gamma-benzyl L-glutamate)-beta-cyclodextrin |
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Authors: | Barbosa Ma Elisa Martínez Bouteiller Laurent Cammas-Marion Sandrine Montembault Véronique Fontaine Laurent Ponchel Gilles |
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Affiliation: | UMR CNRS 8612, Laboratoire de Pharmacotechnie et Biopharmacie, Faculté de Pharmacie, Université Paris-Sud, 5 rue J. B. Clément, 92290 Chatenay-Malabry, France. |
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Abstract: | Imparting desired technological characteristics to polymeric nanoparticles requires the development of original polymers. In the present work, the synthesis and characterization of a novel PBLG-derivative, the poly(gamma-benzyl L-glutamate)-beta-cyclodextrin (PBLG-beta-CD-50), have been carried out. Nanoparticles from either PBLG-beta-CD-50 polymer or from mixtures with PBLG have been prepared using a modified nanoprecipitation method. Spherically shaped nanoparticles with diameter in the range of 50-70 nm were obtained, as determined by dynamic laser light scattering and transmission electron microscopy. The presence of a surfactant in the suspension medium had almost no influence on these parameters and was not necessary to the shelf-stability of the suspension. Further, isothermal titration microcalorimetry (ITC) experiments have been used to show unambiguously that about 20% of the cyclodextrins remain functional within the particles. Consequently, this system may be of interest when association of large amounts of hydrophobic drugs to nanoparticles is required. |
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Keywords: | Poly(γ‐benzyl L‐glutamate)‐β‐cyclodextrin multifunctional nanoparticles PBLG nanoparticles nanoprecipitation inclusion ITC |
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