Effect of stimulation of mu-opiate receptors on contractility of the isolated heart in normal oxygenation and during ischemia-reperfusion] |
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| Authors: | T V Lasukova L N Maslov Iu B Lishmanov S V Tam G J Gross |
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| Institution: | Institute of Cardiology, Kievskaya St., 111, 634050 Tomsk, Russia. |
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| Abstract: | Activation of mu-opioid receptor (OR) in rats prevented development of reperfusion-induced myocardial cell damage. In contrast, direct cardiac mu-OR stimulation with the opioid receptor agonist DAMGO decreased cardiac contractility in normal oxygenation and aggravated the reperfusion-induced myocardial cell damage. The findings suggest that the cardioprotective effect of mu-OR stimulation is not mediated via cardiac mu-OR activation. |
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